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KMID : 0861020230380060053
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Korea Journal of Herbology
2023 Volume.38 No. 6 p.53 ~ p.60
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Vasorelaxant effects of 10 traditional Korean Herbal Prescriptions on isolated rat aortic rings
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Park Eun-Jeong
Kim Bum-Jung
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Abstract
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Objectives : The objective of present study was to investigate the vasorelaxant effects of 10 traditional Korean Herbal
Prescriptions (KHP) on isolated rat thoracic aorta precontracted with potassium chloride (KCl).
Methods : An electric extractor was used to extract KHP in distilled water for 3h. Rat aorta rings were isolated and were precontracted using KCl in organ chambers containing 10 ml Krebs Henseleit (KH) buffer. KHP extracts were added in increasing concentrations (10-1000 μg/㎖) to investigate vasorelaxant effects. The vasorelaxant responses induced by KHP were expressed as a percentage in response to contraction generated by KCl.
Results : Among the 10 KHP, Gamisoyo-san, Galgeun-tang, Gyeji-tang, Gwakhyangjeonggi-san, Daeyoung-jeon,
and Socheongryong-tang showed significant vasorelaxant effect at high concentration. In contrast, Gyejibokryeonghwan constricted more the aorta rings precontracted by KCl. And Gumiganghwal-tang, Guibi-tang, Saengmaek- san showed no significant effect. Also, rat aorta rings treated with Gyejibokryeong-hwan or Gyeji-tang after prerelaxation by amlodipine did not cause any significant change.
Conclusion : Thus, these results provide the experimental evidence as useful herbal prescriptions for the treatment of hypertension and suggest guidelines in conjunction with other western drugs, including amlodipine.
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KEYWORD
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Korean Herbal Prescriptions, amlodipine, hypertension, vasorelaxation, vasoconstriction
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